Can Smoking Cause Dementia? Korean Researchers Say Yes

While smoking is commonly known to be extremely harmful to one’s health, most people associate smoking with lung cancer, emphysema, or even heart disease. However, there are other long-term health effects associated with smoking that scientists are just starting to understand.

Researchers in South Korea concluded that cigarette smoking increases one’s likelihood of getting dementia, while quitting or even smoking less can decrease one’s likelihood. This was based on a study they conducted on the relationship between smoking cessation and dementia.

The Study

shoulderpain2-300x199The study, which was funded by the Seoul National University Hospital, examined 46,140 men, who were 60 years and older. Their objective was to figure out the relationship between developing dementia and quitting smoking. The data they gathered spanned the years between 2002 and 2013.

The first part of the study involved having the participants undergo two health examinations that were each followed by a questionnaire. This took place over the span of three years. The first questionnaires and examinations took place between 2002 and 2003. The second ones took place between 2004 and 2005. Based on the two questionnaires, researchers grouped participants into four different categories. These categories were continual smokers, short-term quitters, long-term quitters, and never smokers. Continual smokers were participants who remained smokers throughout both questionnaires. Short-term quitters were participants who were smokers during the first questionnaire but quit by the second one. Long-term quitters were individuals who were previously smokers but quit by the first questionnaire. Never smokers were participants who had never smoked.

Following the second questionnaire and examination, researchers followed up with each participant for the next eight years, starting on January 1, 2006. Participant’s role in the study would end on December 31, 2013. Some participants ended their role in the study due to death or dementia diagnosis prior to the aforementioned date. Participants were followed-up for any development of overall dementia, Alzheimer’s disease, and vascular dementia.

Results

Researchers noted that long-term quitters and never smokers were less at risk of overall dementia. Never smokers were less at risk of Alzheimer’s compared to continual smokers. Both long-term quitters and never smokes were less at risk for vascular dementia than continual smokers. Men who quit for up to four years had a 13% lower risk of dementia, while men who quit for four years or more had a 14% lower risk. Never smokers had a 19% lower risk.

Conclusion

The researchers felt that their results showed that smoking increased one’s risk of developing dementia. They also noted that smokers who quit for a long period of time can decrease that risk. They felt that smokers should be encouraged to stop, in order to reduce their risk of developing dementia, especially elderly people, who are already at high risk.

The researchers, however, noted some limitations to their study. They felt as if eight years was not enough time to carefully determine whether or not quitting smoking can significantly impact the risk of developing Alzheimer’s. They also did not consider other neurodegenerative diseases such as Parkinson’s or ALS. The researchers note that future studies involving a longer follow-up duration and the inclusion of other neurological diseases can help validate the results of this study. Changes in smoking habit were not accounted for during the second health examination. They also noted that because smoking statuses were determined by questionnaire, researchers might not have the exact smoking status of each participant.

However, in spite of these limitations, researchers noted that smokers should quit smoking in order to reduce their risk of developing dementia. They felt that there should be proper education about the benefit of quitting smoking.