Our lawyers are investigating possible Nexium bone fracture lawsuits.
Overview of Nexium
Nexium (esomeprazole magnesium), produced by AstraZeneca, is approved by the Federal Drug Administration (FDA) for the treatment of the following conditions: Dyspepsia, Peptic ulcer disease (PUD), Gastroesophageal reflux disease (GERD), Laryngopharyngeal reflux, Barrett's esophagus, the prevention of stress gastritis, Gastrinomas and other conditions that cause hypersecretion of acid and Zollinger-Ellison syndrome. It can be administered by injection through an IV or can be taken orally as a capsule in twenty or forty milligram dosages which are taken once or twice per day for a period of not more than fourteen days as recommended by the FDA. The medication is now produced by several pharmaceutical companies under the names, Prilosec, Aciphex, Dexilant, Zegrid, Prevacid, and Protonix. Nexium (esomeprazole) is AstraZeneca’s best-selling drug and the third best-selling medication in the world, with over $5.2 billion in sales in 2008.
The medicine belongs to a class of drug called Proton Pump Inhibitors (PHI). Their main function is a pronounced and long-lasting reduction of gastric acid production. This group of drugs followed and has largely replaced the use of H2-receptor antagonists with similar effects, but different mode-of-action. The main difference between the two classes are PPI’s stop proton pumps in the stomach from producing gastric acid, whereas the H2’s block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells.
Generally, Nexium and other drugs of this type are well tolerated by patients and adverse effects from short-term use are not very common. Although adverse side effects are reported more often with the use of omeprazole, the same risks apply for all PPI’s. It is believed the occurrence is elevated in the use Nexium and similar medications because they are prescribed more than other PPI’s. Common side effects include: headache, nausea, diarrhea, abdominal pain, fatigue, and dizziness. Long-term use of PPI’s has been linked to hypomagnesemia. Because the body uses gastric acid to release B12 from food particles, decreased vitamin B12 absorption may occur with long-term use of proton-pump inhibitors and may lead to Vitamin B12 deficiency. Infrequent adverse effects include rash, itch, flatulence, constipation, anxiety, and depression. Rarely PPI cause ‘idiosyncratic’ reactions such as erythema multiforme pancreatitis, Stevens Johnson syndrome, and acute interstitial nephritis.
Also, studies have shown using H2-receptor antagonists and proton pump inhibitors, are associated with an increased risk of community-acquired pneumonia. It is suspected that acid suppression results in insufficient elimination of pathogenic organisms, suggesting that patients at higher risk of pneumonia should be prescribed PPI’s only at lower doses and only when necessary. PPIs have been shown to raise risk of Clostridium difficile infection by 1.7 times with once daily use and 2.4 times with more than once daily use. The risk can be minimized by judicious short term prescriptions.
Nexium Hip Fractures
Long-term use of proton pump inhibitors has been less studied. Potential Nexium bone fracture lawsuits are going to need future studies to confirm where plaintiffs' lawyers think the evidence is going to play out. One thing is for sure that no one needs to study: a hip fracture is an awful thing.
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